MECHANISM 01
Reduced fat accumulation in adipocytes
Curcumin activates AMPK (AMP-activated protein kinase), suppressing fat storage and promoting fatty acid oxidation.
← BOMFIT EnglishA Korean national patent, neurosurgery-led research,
Science & Research
A Korean national patent, neurosurgery-led research,
and an in-house turmeric farm —
the scientific foundation of BOMFIT.
BOMFIT's flagship ingredient ST-01 leverages South Korean national patent No. 10-2523211 for a fermented turmeric extract. Co-developed with neurosurgery experts from Seoul National University Medical School and cultivated pesticide-free on the brand's own farm on Geoje Island.
10-2523211
National patent
7
Mechanisms of action
3
Peer-reviewed papers
Geoje
Own pesticide-free farm
01 · National Patent
South Korean national patent on
fermented turmeric extract — No. 10-2523211
BOMFIT's key functional ingredient ST-01 leverages a national patent registered with the Korean Intellectual Property Office (KIPO). The patent is held by the Republic of Korea, with the Rural Development Administration (RDA) as the succession authority — making it a public R&D asset.
Patent Number
10-2523211
Application Number
10-2021-0161657
Filing Date
2021-11-22
Registration Date
2023-04-14
Expiration Date
2041-11-22
Patentee
Republic of Korea (KIPO / RDA)
Title of Invention
Method for producing turmeric extract and fermented turmeric containing curcumin, demethoxycurcumin, and bisdemethoxycurcumin, and composition for preventing or improving obesity comprising the same.
IPC Classification
A23L 33/105A23L 33/135A61K 36/9066A61P 3/04
※ The patent is owned by the Republic of Korea; BOMFIT applies the technology to manufacture its ST-01 ingredient. Registration can be verified by anyone via KIPRIS (https://www.kipris.or.kr).
02 · ST-01 Mechanisms
Seven mechanisms of action
of the ST-01 turmeric extract
Sociotech BIO HEALTH LAB summarizes the body fat reduction and anti-inflammatory mechanisms of ST-01 across seven canonical molecular pathways covering obesity and metabolic regulation.
AMPK activation
MECHANISM 02
Inhibition of adipocyte differentiation
Down-regulation of key adipogenic transcription factors PPARγ (Peroxisome Proliferator-Activated Receptor Gamma) and C/EBPα (CCAAT/enhancer-binding protein alpha).
MECHANISM 03
Enhanced fatty acid oxidation
Up-regulation of fatty acid oxidation genes such as CPT-1 (Carnitine Palmitoyltransferase-1) to convert stored fat into energy.
MECHANISM 04
Anti-inflammatory action
Suppression of inflammatory cytokines NF-κB (Nuclear Factor-kappa B) and TNF-α (Tumor Necrosis Factor-alpha) reduces low-grade chronic inflammation.
MECHANISM 05
Gut microbiota modulation
Increases probiotics and short-chain fatty acid (SCFA) producing bacteria while suppressing obesity-associated harmful bacteria — restoring the gut-metabolic axis.
MECHANISM 06
Brown adipose tissue (BAT) activation & thermogenesis
Increases UCP-1 (Uncoupling Protein-1) expression in brown adipose tissue, raising thermogenesis and basal metabolic rate.
MECHANISM 07
Improved insulin sensitivity
Activates the PI3K-Akt signalling pathway and increases IRS-1 (Insulin Receptor Substrate-1) phosphorylation, improving glucose control and insulin sensitivity.
※ The mechanisms above describe scientific findings on Curcuma longa and its derivatives in academic research. They do not constitute clinical efficacy claims for the BOMFIT finished product. BOMFIT is a general food / health supplement, not a drug.
03 · Peer-Reviewed Research
Three peer-reviewed studies
on turmeric & curcumin metabolism
Lipids in Health and Disease·2020·Kundimi et al. (2020) 19:198
Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats
https://doi.org/10.1186/s12944-020-01376-7Journal of Functional Foods·2024·Lee et al., Vol. 122 (2024) 106490
Curcuma longa rhizome extract activates brown adipocytes and inhibits lipogenesis in high-fat diet-fed mice
https://www.sciencedirect.com/journal/journal-of-functional-foodsJournal of Agricultural and Food Chemistry·2024·Koh et al., 72, 14786–14798
Structural Variances in Curcumin Degradants: Impact on Obesity in Mice
https://pubs.acs.org/journal/jafcau04 · Medical Advisors
Board-certified neurosurgeons
from Seoul National University Medical School
Dr. Sang-hun Yoon
Lead Researcher · Board-certified Neurosurgeon
- ·Ph.D., Seoul National University College of Medicine
- ·Former Assistant Professor, Department of Neurosurgery, Seoul National University Bundang Hospital
- ·Director of Neurosurgery, Gangseo Himchan Hospital (current)
Prof. Byung-kyu Cho
Standing Advisor, Sociotech BIO HEALTH LAB · Board-certified Neurosurgeon
- ·Emeritus Professor, Seoul National University College of Medicine
- ·Standing Advisor for Sociotech, supplier of BOMFIT's ST-01 ingredient
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※ The academic content on this page describes general mechanisms of Curcuma longa and its derivatives. It does not constitute clinical efficacy claims for BOMFIT finished products.
※ BOMFIT is a general food / health supplement, not a drug, and is not intended for diagnosis, treatment, or prevention of any disease. Pregnant or breastfeeding individuals, those with health conditions, or those taking medication should consult a professional before use.
※ Patent No. 10-2523211 is owned by the Republic of Korea, managed by the Korean Intellectual Property Office, with the Rural Development Administration as the succession authority. Registration can be verified by anyone via KIPRIS (https://www.kipris.or.kr).